Diabetes Home > Amaryl Warnings and Precautions

Some Amaryl warnings and precautions include the risk of death due to heart or blood vessel problems and potential drug interactions. Prior to taking Amaryl, you should talk to your healthcare provider about any health conditions you may have, such as kidney or liver problems, adrenal insufficiency, or any allergies. You should not take Amaryl if you are allergic to any ingredient used to make Amaryl or if you have diabetic ketoacidosis.

Amaryl: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Amaryl® (glimepiride) if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Glucose 6-phosphate dehydrogenase deficiency (G6PD deficiency) 
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Will be having surgery.
Make sure to tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Amaryl Precautions and Warnings

Patients taking Amaryl should be aware of the following precautions and warnings:
  • Oral diabetes medicines, including Amaryl, may increase the risk of death due to heart or blood vessel problems compared to diabetes treatment using diet or insulin. This warning is based on one research study that looked at a medication similar to Amaryl. It is unclear at this time how important this risk may be in people taking Amaryl.
  • If you are allergic to sulfonamides ("sulfa" medications), you may also be allergic to Amaryl. Let your healthcare provider know if you have a sulfa allergy.


  • In people with glucose 6-phosphate dehydrogenase deficiency (G6PD deficiency), it is possible that Amaryl might increase the risk of a dangerous problem known as hemolytic anemia. A few cases have even been reported in people that did not have G6PD deficiency. Let your healthcare provider know if you develop signs of hemolytic anemia, such as:
    • Pale skin
    • Fatigue
    • A rapid heart rate
    • Yellow skin (jaundice)
    • Shortness of breath
    • Dark urine.
  • Amaryl can interact with certain medications (see Amaryl Drug Interactions).
  • Amaryl is considered a pregnancy Category C medication. This means that Amaryl may not be safe during pregnancy. Talk with your healthcare provider about taking Amaryl during pregnancy (see Amaryl and Pregnancy for more information).
  • It is not known if Amaryl passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this.
  • Amaryl can cause low blood sugar (hypoglycemia) in some people. This has been more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise. Low blood sugar symptoms may include irritability, trembling, cold sweats, or blurry vision, among other things (see Amaryl and Blood Sugar for more information).
  • Fever, infections, injury, or surgery can temporarily increase your blood sugar, even in people with well-controlled diabetes. Amaryl may not be enough to treat your diabetes at these times, and the use of insulin may be required. Contact your healthcare provider if you have a fever, infection, injury, or will be having surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels (see Amaryl and Blood Sugar for more information).
  • Over time, Amaryl may become less effective at controlling blood sugar levels. This may be because your diabetes has gotten worse or your body is not responding as well to the Amaryl. In these cases, Amaryl may need to be combined with another oral diabetes medication or insulin. You healthcare provider may also recommend switching diabetes medication (see Amaryl Alternatives).
  • Sulfonylurea medicines, such as Amaryl, have been reported to increase sensitivity to the sun. Therefore, when going outdoors, try wearing long sleeves, pants, and a hat. Any exposed skin should be covered with sunscreen that is at least SPF 15.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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