Diabetes Home > Amaryl Drug Interactions

Certain decongestants, some seizure medications, and diuretics can interact with Amaryl and change the way the medications are absorbed into the blood. Some of these drug interactions with Amaryl can increase your risk of low blood sugar or increase the level of Amaryl in your blood, potentially increasing your risk of side effects.

An Overview of Amaryl Interactions

Amaryl® (glimepiride) can potentially interact with many drugs. Some of the drugs that may lead to Amaryl interactions include:



  • Chloramphenicol (Chloromycetin®)
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
  • Estrogens


  • Isoniazid
  • Monoamine oxidase inhibitors (MAOIs), including
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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