Diabetes Home > Actoplus Met Uses
Actoplus Met uses typically include the treatment of type 2 diabetes. The drug helps improve insulin sensitivity, decrease sugar absorption into the body, and make insulin receptors more sensitive. It is currently not approved for use in children. Off-label Actoplus Met uses may include the treatment of polycystic ovarian syndrome.
Actoplus Met® (pioglitazone and metformin) is a prescription medication that is used to treat type 2 diabetes. The drug combines two different diabetes medications: pioglitazone hydrochloride (Actos®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®).
Type 2 diabetes is the most common type of diabetes (see Diabetes Types). It is also sometimes called adult-onset diabetes or non-insulin-dependent diabetes. Type 2 diabetes is a condition involving insulin resistance. With insulin resistance, cells in the body do not respond to insulin as well as they normally should. As a result, the cells do not take sugar out of the blood very well. This is why people with type 2 diabetes have high blood sugar.
Over time, high blood sugar can lead to a number of problems, including:
(Click Diabetes Complications for more information.)
The cause of type 2 diabetes is not fully understood, although it is known that obesity and genetics play an important role in type 2 diabetes.
If blood sugar cannot be lowered enough through lifestyle changes (such as weight loss, diet, and exercise), a medication for type 2 diabetes, such as Actoplus Met, may be prescribed. The two medications in it work differently and have different effects in the body:
- Pioglitazone is part of a group of diabetes medicines called thiazolidinediones (or sometimes called "glitazones"). Pioglitazone helps to improve insulin sensitivity. This means that pioglitazone helps your body respond to its natural insulin better, which helps to lower blood sugar.
- Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. Metformin can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels.