Diabetes Home > Actoplus Met Risks

People with type 2 diabetes may find Actoplus Met® (pioglitazone and metformin) to be an effective medication for their situation. It combines two different active ingredients, comes in the form of a tablet, and is usually taken one or two times a day.
 
Although no medication is entirely free from risk, Actoplus Met is generally well tolerated; if side effects occur, they are generally mild and easily treated. However, there are some important safety warnings to review with your healthcare provider before beginning treatment. This includes being aware of potentially serious adverse reactions and knowing when to seek medical attention.
 
People with a history of heart failure (especially congestive heart failure), kidney problems, or liver disease need to use Actoplus Met with care. This medication can make such conditions worse or -- in rare cases -- even cause them. Lactic acidosis is one of the most serious Actoplus Met risks. If you experience possible signs, such as unexplained muscle pain or trouble breathing, contact your doctor right away.
 
(To learn more about these and other risks, click Actoplus Met Side Effects. This article describes other problems that may occur during treatment, how often they occurred in clinical trials, and how clinical trials work.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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