Diabetes Home > Actoplus Met Drug Interactions

Isoniazid
Taking Actoplus Met with isoniazid can make Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping isoniazid.
 
Niacin
If Actoplus Met and niacin are taken together, this makes Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping niacin.
 
Oral Contraceptives
If Actoplus Met and oral contraceptives (birth control pills) are combined, this can make Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). To prevent this interaction, you may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking Actoplus Met with phenothiazines can make Actoplus Met less effective, possibly increasing your chance of high blood sugar (hyperglycemia). As a result, you may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping a phenothiazine.
 
Rifampin or Rifapentine
Taking Actoplus Met and rifampin or rifapentine together can decrease the level of Actoplus Met in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of Actoplus Met to prevent this interaction from occurring.
 
Ritonavir
If Actoplus Met and ritonavir are taken together, this can increase the level of Actoplus Met in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of Actoplus Met to prevent this interaction.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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