Diabetes Home > Actoplus Met Drug Interactions

Cimetidine
Combining Actoplus Met with cimetidine can increase the level of Actoplus Met in your blood, possibly increasing your risk of side effects. Your healthcare provider may adjust your dose of these medications or suggest an alternative to cimetidine, depending on your particular situation.
 
Corticosteroids
Taking Actoplus Met with corticosteroids can make Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping a corticosteroid.
 
Diuretics
If Actoplus Met is taken with diuretics, this can make Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping a diuretic.
 
If Actoplus Met is combined with furosemide (a diuretic), this can affect the levels of both furosemide and Actoplus Met in your blood. This may increase your risk of Actoplus Met side effects and make furosemide less effective. To prevent this drug interaction, your healthcare provider may need to adjust your dose of these medications.
 
Estrogens
Taking Actoplus Met with estrogens can make Actoplus Met less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met dose, especially when starting or stopping an estrogen.
 
Gemfibrozil
Combining Actoplus Met with gemfibrozil can increase the level of Actoplus Met in your blood, possibly increasing your risk of side effects. To prevent this interaction from occurring, your healthcare provider may need to decrease your dose of Actoplus Met.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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