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Oral Diabetes Medicines as Alternatives to Actoplus Met

Fortunately, many different types of oral diabetes drugs are available to treat type 2 diabetes, including:
 
  • Sulfonylureas
  • Biguanides
  • Meglitinides
  • Thiazolidinediones
  • Alpha glucosidase inhibitors
  • Dipeptidyl peptidase inhibitors
  • Ergot alkaloids 
  • Sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors)
  • Bile acid sequestrants
  • Combination medications.
     
Actoplus Met is a combination of a thiazolidinedione (pioglitazone) and a biguanide (metformin).
 
Sulfonylureas
Sulfonylureas are medications that force the pancreas to make more insulin. Because of this, they are very effective in controlling blood sugar, but are also more likely to cause dangerously low blood sugar (hypoglycemia). These medications include:
 
Biguanides
Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®) is the only biguanide medication currently available to treat type 2 diabetes. It works by helping the body use its natural insulin better. It also decreases sugar (glucose) production by the liver and decreases sugar absorption from the diet.
 
Meglitinides
Meglitinides are similar to sulfonylureas in that they force the pancreas to produce more insulin. However, they are short-acting and are less likely to cause dangerously low blood sugar. They are usually taken before every meal. Meglitinides include:
 
Thiazolidinediones
These medications (also called glitazones) work primarily by helping the body use its natural insulin better. These diabetes medications include:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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