Drug Interactions With Losartan (Cont.)

More Detail on Losartan Interactions

 
Diuretics
When you are taking losartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when losartan is first started. In order to decrease the chances of this losartan interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of losartan, and/or monitor you more closely.
 
Potassium Supplements or Salt Substitutes With Potassium
If you are taking losartan with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and losartan together.
 
Potassium-Sparing Diuretics
If you are taking both losartan and a potassium-sparing diuretic, your body may metabolize them differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress more closely.
 
Rifampin (Rifadin, Rimactane, Rofact)
If you are taking losartan and rifampin together, your body may metabolize losartan differently than intended. This can cause a decreased level of losartan in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and adjust your losartan dose as needed.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
If you are taking both losartan and lithium, your body may metabolize the drugs differently than intended and increase the lithium levels in the blood. Your healthcare provider may choose to monitor your blood lithium levels more frequently.
(Drug Interactions With Losartan Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;