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Drug Interactions With Losartan

More Detail on Losartan Interactions

The following sections explain in detail the potentially negative interactions that can occur when losartan is combined with any of the drugs listed above.
 
ACE Inhibitors
Although not an ACE inhibitor, losartan works similarly to ACE inhibitors. Thus, combining these drugs may increase the risk of high potassium levels (hyperkalemia), kidney failure, and dangerously low blood pressure. Careful monitoring is necessary for such combinations.
  
Diuretics
When you are taking losartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when losartan is first started. In order to decrease the chances of this losartan interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of losartan, and/or monitor you more closely.
 
Potassium Supplements or Salt Substitutes With Potassium
If you are taking losartan with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and losartan together.
 
Potassium-Sparing Diuretics
If you are taking both losartan and a potassium-sparing diuretic, your body may metabolize them differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress more closely.
 
Rifampin (Rifadin, Rimactane, Rofact)
If you are taking losartan and rifampin together, your body may metabolize losartan differently than intended. This can cause a decreased level of losartan in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and adjust your losartan dose as needed.
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Losartan Potassium

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