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Kombiglyze XR Drug Interactions

If oral contraceptives, decongestants, antibiotics, or corticosteroids are taken with Kombiglyze XR, drug interactions may occur. These reactions can decrease the effectiveness of Kombiglyze XR, potentially increasing your risk of high blood sugar. If such problems are a concern, your healthcare provider may choose to monitor you more closely or adjust the doses of your medications.

An Overview of Interactions With Kombiglyze XR

Kombiglyze™ XR (saxagliptin/metformin ER) can potentially react with several other medications. Some of these drugs that may lead to interactions with Kombiglyze XR include:
  • Certain antibiotics or antifungal medications, such as:
  • Cimetidine (Tagamet®)
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
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Kombiglyze XR Medication Information

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