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Kombiglyze XR Drug Interactions

Isoniazid
Taking Kombiglyze XR with isoniazid can make Kombiglyze XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Kombiglyze XR dose, especially when starting or stopping isoniazid.
 
Nefazodone
Because nefazodone may increase the level of Kombiglyze XR in the bloodstream, a lower Kombiglyze XR dosage (2.5 mg/1000 mg daily) is usually recommended for use in combination with nefazodone. Check with your healthcare provider before taking these medicines together.
 
Niacin
Taking Kombiglyze XR with niacin can make Kombiglyze XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Kombiglyze XR dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Combining Kombiglyze XR with oral contraceptives (birth control pills) can make Kombiglyze XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Kombiglyze XR dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking Kombiglyze XR with phenothiazines can make Kombiglyze XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Kombiglyze XR dose, especially when starting or stopping a phenothiazine.
 
Phenytoin
Combining Kombiglyze XR with phenytoin can make Kombiglyze XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Kombiglyze XR dose, especially when starting or stopping phenytoin.
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Kombiglyze XR Medication Information

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