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Kombiglyze XR and Breastfeeding

Women who are breastfeeding should use Kombiglyze XR with caution, since the effects the drug could have on a nursing child are unknown. The manufacturer recommends that breastfeeding women avoid the drug; however, there are situations when its use may be recommended. Your healthcare provider will weigh the benefits and risks in your particular situation.

Can Breastfeeding Women Use Kombiglyze XR?

At this time, it is unknown if Kombiglyze™ XR (saxagliptin/metformin ER) is safe for use by breastfeeding women. The manufacturer states that it should be used with caution in such cases. Therefore, you should talk with your healthcare provider before taking it if you are breastfeeding or plan to start.

What Is the Risk?

Saxagliptin (one of the active ingredients in Kombiglyze XR) is known to pass through breast milk in rats, although it is unknown if the same is true for humans. The other ingredient, metformin, does pass through breast milk in humans (see Metformin and Breastfeeding).


It is unknown if Kombiglyze XR exposure through breast milk would have any noticeable or negative effects on a breastfeeding child.
If your healthcare provider recommends that you take Kombiglyze XR while breastfeeding, be sure to watch for any adverse reactions or changes in your child.

Talking With Your Healthcare Provider

You should discuss breastfeeding and Kombiglyze XR use with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
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Kombiglyze XR Medication Information

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