Effects on Blood Sugar Levels
In the same study, people given metformin with alogliptin had a decrease in their fasting blood sugar by 32 mg/dL to 46 mg/dL, on average. In comparison, metformin alone lowered fasting blood glucose by 12 mg/dL to 32 mg/dL, on average, and alogliptin alone by 10 mg/dL, on average.
How Does Kazano Work?
As mentioned already, Kazano contains two diabetes medicines: alogliptin and metformin. These two medicines work in different ways to control blood sugar.
Alogliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These hormones cause insulin to be released from the pancreas (which lowers blood glucose levels) in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
By blocking the DPP-4 enzyme, Kazano increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals, and reduces the amount of glucose made by the liver.
Metformin belongs to a group of medicines known as biguanides. It lowers blood sugar levels in several ways, including by:
- Decreasing the amount of glucose made by the liver
- Decreasing the amount of sugar absorbed into the body through the small intestines
- Improving insulin sensitivity, which helps increase glucose uptake and use by cells.
When and How to Take It
General considerations to keep in mind during treatment with Kazano include the following:
- This medication comes in the form of a tablet. It is usually taken by mouth twice a day.
- Make sure to take Kazano with food to minimize the risk for stomach upset.
- Do not crush, cut, chew, or break Kazano tablets. They must be swallowed whole.
- Take your doses at about the same time each day to keep an even level of the drug in your bloodstream.
- For Kazano to work properly, it must be taken as prescribed. Do not stop taking it or take a different dose without your healthcare provider's approval.