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Kazano and Pregnancy

In animal studies, the two active ingredients in Kazano (alogliptin and metformin) did not appear to cause birth defects or other problems. However, animals and humans can respond to the same drug in different ways. Although it is generally considered safe for women to use Kazano during pregnancy, this drug should only be used if the benefits outweigh the risks.

 

Can Pregnant Women Take Kazano?

Kazano® (alogliptin and metformin) is a combination diabetes medication that contains metformin (Glucophage®) and alogliptin (Nesina®) together in one pill. Based on animal studies, Kazano is generally considered safe for use by women who are pregnant.
 

What Is Pregnancy Category B?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Kazano is classified as a pregnancy Category B medication.
 
Pregnancy Category B is given to medicines that have not been adequately studied in pregnant women but do not appear to cause harm to the fetus in animal studies. Medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a Category B rating.
 
Kazano has not been studied in pregnant women. However, the two active components have been studied together in pregnant animals. In these studies, the combination of metformin and alogliptin did not cause birth defects or other problems when given to pregnant rats. Metformin and alogliptin also did not cause problems when given separately to pregnant rats and rabbits.
 
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category B medicine, including Kazano, should be given to a pregnant woman only if her healthcare provider believes that the benefits to the woman outweigh any possible risks to her unborn child.
 
If you have diabetes, it is important to work closely with your healthcare provider if you are pregnant or are thinking of becoming pregnant. Inadequate blood glucose control during pregnancy can harm you and your baby. Therefore, you will need to discuss with your healthcare provider the best ways to monitor and control your blood glucose while you are pregnant.
 
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