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Kazano and Breastfeeding

Although one of the active ingredients in Kazano (alogliptin and metformin) has been studied in breastfeeding women, it is unknown whether the drug passes through human breast milk. Therefore, the problems it might cause are unknown. The manufacturer recommends women use Kazano with caution while breastfeeding. Your healthcare provider will make a recommendation based on your particular situation.

Can Breastfeeding Women Take Kazano?

Kazano® (alogliptin and metformin) is a prescription diabetes medication that contains a combination of metformin (Glucophage®), a biguanide diabetes medicine, and alogliptin (Nesina®), a dipeptidyl peptidase-4 (DPP-4) inhibitor. At this time, it is unknown if Kazano passes through breast milk in women. If you are currently breastfeeding or plan to start, talk to your healthcare provider before taking the medication.

More Information on Kazano and Breastfeeding

Kazano has not been studied in breastfeeding women. Therefore, it is unknown if the drug passes through human breast milk, or if it would harm a nursing infant.
The individual components of Kazano, metformin and alogliptin, have been shown to pass through the breast milk of rats. In addition, studies have shown that metformin passes through human breast milk. In these studies, researchers have estimated that a nursing infant would only ingest a small amount of metformin -- between 0.11 percent and 0.65 percent of the mother's dose. Furthermore, studies have reported normal blood sugar levels in babies four hours after breastfeeding.
The manufacturer recommends Kazano be used with caution in breastfeeding women. If your healthcare provider recommends this drug while you are breastfeeding, make sure to watch your child for any possible Kazano side effects, and contact your child's healthcare provider if you notice anything of potential concern.  
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