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Jentadueto is a combination medication prescribed to help control blood sugar levels in people with type 2 diabetes. It comes as a tablet and is taken twice daily with meals. This diabetes drug works in several ways, such as reducing production of sugar produced by the liver and increasing insulin production. Possible side effects include a sore throat, runny nose, and diarrhea.

What Is Jentadueto?

Jentadueto™ (linagliptin/metformin) is a prescription diabetes medication approved to treat type 2 diabetes in adults. It contains a combination of linagliptin (Tradjenta™) and metformin (Glucophage®).
(Click Jentadueto Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Jentadueto is marketed by Boehringer Ingelheim Pharmaceuticals, Inc., and Eli Lilly and Company.

How Does Jentadueto Work?

Jentadueto contains two different diabetes medications. Linagliptin belongs to a class of diabetes drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, linagliptin slows the breakdown of incretin hormones, increasing the level of these hormones in the body.
It is this increase in incretin hormones that is responsible for the beneficial actions of linagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Because incretin hormones are more active in response to higher blood sugar levels, the risk of dangerously low blood sugar (hypoglycemia) is low with linagliptin.
Jentadueto also contains metformin, a biguanide medication. Metformin works in several ways, such as:
  • Decreasing the amount of sugar (glucose) the liver produces
  • Reducing the amount of sugar the body absorbs from the diet
  • Increasing the sensitivity of insulin receptors to improve how the body responds to its own insulin.
All of these effects help to control blood sugar levels.
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Jentadueto Medication Information

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