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Jentadueto Warnings and Precautions

People who plan to treat diabetes with Jentadueto should know that this drug may increase the risk for dangerous complications, including lactic acidosis, liver disease, and other medical issues. In addition, safety precautions for taking Jentadueto include warnings for women who are pregnant or nursing, as well as those who are taking certain medications or supplements.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Jentadueto™ (linagliptin/metformin) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • An alcohol problem
  • An upcoming radiology procedure that will require the use of contrast dye
  • Pernicious anemia
  • Type 1 diabetes
  • Diabetic ketoacidosis
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Jentadueto

Some warnings and precautions to be aware of prior to taking this medication include the following:
 
  • Very rarely, the metformin component of Jentadueto may cause a life-threatening condition called lactic acidosis (see Metformin and Lactic Acidosis). The risk increases if other medical conditions are present, including:
 
 
Drinking alcohol can also increase your risk for lactic acidosis. Drinking large amounts of alcohol on a regular basis or drinking a large amount at once (binge drinking) should be avoided while taking Jentadueto (see Metformin and Alcohol).
 
  • Because liver disease, including liver failure and cirrhosis, can increase your risk for lactic acidosis, you should not take Jentadueto if your liver is not functioning normally.
 
  • Your kidney function needs to be monitored while you are taking Jentadueto. This means that you should have blood tests to check your kidneys before you start taking it, and then at least once every year. If your kidney function is very poor, you should not take this drug, as it can increase the risk for lactic acidosis.
 
  • Taking Jentadueto and contrast dye at the same time can increase your risk for kidney damage. Contrast dye is used for certain radiology procedures, including some x-rays, computed tomography (CT) scans, and heart catheterizations (see Metformin and Contrast Medium). Also, this drug should be stopped temporarily for most major surgeries and restarted when you are eating normally again.
 
  • Fever, infections, injury, or surgery can increase your blood sugar levels temporarily, even in people who have well-controlled diabetes. Jentadueto may not be sufficient to treat your diabetes during these times, and you may need to use insulin. Contact your healthcare provider if you have a fever, infection, injury, or an upcoming surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels.
 
  • Let your healthcare provider know if you have an illness that causes severe vomiting, diarrhea, or fever, or if you drink a much lower amount of liquid than normal. These conditions can lead to severe dehydration (loss of water in your body). You may need to stop taking Jentadueto for a short time.
 
  • Jentadueto can decrease your levels of vitamin B12. Your healthcare provider should monitor your vitamin B12 levels, especially if you have a vitamin B12 deficiency like pernicious anemia.
 
  • In rare cases, Jentadueto can cause low blood sugar levels (hypoglycemia), usually when it is combined with other diabetes medications. This is more common in elderly people; those who have problems with their adrenal gland, pituitary gland, liver, or kidneys; and people who are fasting before surgery or have finished prolonged exercise. Low blood sugar symptoms may include:
 
    • Irritability
    • Trembling
    • Cold sweats
    • Blurry vision.
 
 
  • Jentadueto is a pregnancy Category B medication. This means that it is probably safe for use in pregnant women, although the full risks are currently unknown. Talk to your healthcare provider before taking this medication during pregnancy (see Jentadueto and Pregnancy).
 
  • At least one of the active ingredients in Jentadueto passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider about using this drug (see Jentadueto and Breastfeeding).
 
Type 2 Diabetes: Fact or Fiction

Jentadueto Medication Information

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