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Janumet XR Warnings and Precautions

There are some cases when Janumet XR may not be safe or appropriate to use, such as in people who have had a heart attack or stroke or in those who have an alcohol problem. Other warnings for safely using Janumet XR include precautions for people who have certain medical procedures coming up and women who are pregnant or nursing.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Janumet® XR (sitagliptin and metformin extended-release) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Had pancreatitis (inflammation of the pancreas)
  • Congestive heart failure or other heart problems
  • A history of a heart attack or stroke
  • Gallstones
  • Plans for a surgery or medical procedure, including x-rays or procedures where you will be given an injection of dye or contrast agent
  • A condition called metabolic acidosis or if you have had diabetic ketoacidosis (increased ketones in your blood or urine)
  • Low vitamin B12 levels (pernicious anemia)
  • A history of alcoholism or drink alcohol often
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
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Janumet XR Medication Information

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