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Janumet XR Uses

How Does Janumet XR Work?

As mentioned, Janumet XR contains sitagliptin and metformin ER. These two medicines work in different ways to control blood sugar.
Sitagliptin belongs to a group of medicines known as DPP-4 inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These cause insulin to be released from the pancreas in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
By blocking the DPP-4 enzyme, Janumet XR increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals and less glucose to be made by the liver.
Metformin belongs to a group of medicines known as biguanides. It lowers blood sugar levels in several ways, such as:
  • Decreasing the amount of glucose made by the liver
  • Decreasing the amount of sugar absorbed into the body through the small intestines
  • Improving insulin sensitivity, which helps increase glucose uptake and use by cells.
Janumet XR contains the extended-release version of metformin. Metformin extended-release stays in the body longer than regular metformin, so it only needs to be taken once a day.

Is It Safe for Children to Use It?

Janumet XR is only approved for use in adults 18 years of age and older. It has not been adequately studied in individuals younger than this. Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Can Older Adults Use Janumet XR?

Older adults can use this medication. However, Janumet XR should only be used in people whose kidneys function normally. Because kidney function naturally declines with age, this medication may not be appropriate for some older adults. Your healthcare provider will check your kidney function before you start this drug and periodically during treatment.
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Janumet XR Medication Information

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