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Janumet XR Overdose

It is possible to overdose on Janumet XR (sitagliptin and metformin extended-release). Based on one reported case of a person who took too much of one of the ingredients in this combination medication, possible effects may include blurred vision, seizures, and even death. Treatment can involve IV fluids and supportive care, among other things.

Can You Take Too Much Janumet XR?

Janumet® XR (sitagliptin and metformin extended-release) is a prescription medication approved to treat type 2 diabetes. As with any medicine, it is possible to take too much Janumet XR. The effects of an overdose would likely vary, depending on a number of factors, including the Janumet XR dosage and whether it was taken with any other medications or substances.

Symptoms of an Overdose

Based on reports of an overdose of metformin, one of the active components in Janumet XR, the possible effects of an overdose with this product may include but are not limited to:
  • Low blood sugar (hypoglycemia), which could cause:
    • Sweating
    • Shakiness
    • A fast heartbeat
    • Hunger
    • Dizziness
    • Blurry vision
    • Confusion
    • Mood changes, such as irritability
    • Seizures
    • Coma
    • Loss of life
  • Lactic acidosis (too much lactic acid in the bloodstream), which could cause:
    • Muscle pain
    • Abdominal (stomach) pain
    • Feeling extremely sleepy, tired, or weak
    • Feeling cold
    • Problems breathing
    • Dizziness or lightheadedness
    • A slow or irregular heartbeat
    • Loss of life.

Treating a Janumet XR Overdose

If the Janumet XR overdose was recent, a healthcare provider may administer activated charcoal or "pump the stomach" to help reduce the amount of the medication absorbed into the bloodstream. Dialysis may also be used to remove some of the medication from the body.
Treatment will also involve supportive care, which consists of treating the symptoms that occur as a result of the overdose. This may include:
  • Fluids through a needle inserted into a vein (intravenous, or IV, fluids)
  • A glucose solution to increase blood sugar
  • Close monitoring of the heart, heart rate, and blood pressure
  • Other treatments to relieve symptoms that occur.
Seek immediate medical attention if you believe you or someone else may have taken too much Janumet XR.
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Janumet XR Medication Information

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