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Janumet XR Drug Interactions

Janumet XR Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Janumet XR is combined with any of the drugs listed above.
 
Calcium Channel Blockers
Because calcium channel blockers can increase blood glucose (sugar) levels, taking them with Janumet XR could make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dosage, if you start or stop taking a calcium channel blocker. 
 
Carbonic Anhydrase Inhibitors
Taking Janumet XR with medications known as carbonic anhydrase inhibitors could increase your risk for lactic acidosis, a potentially serious problem caused by an accumulation of acid in the blood. These medications can be used together, but should be done so with caution.
 
Certain Decongestants
Because certain decongestants can cause high blood glucose levels (hyperglycemia) taking them with Janumet XR could make Janumet XR less effective. Decongestants are in many cough and cold products, so talk to your healthcare provider or pharmacist before taking any cough or cold medication during your diabetes treatment.
 
Cimetidine and Ranitidine
Taking Janumet XR with cimetidine or ranitidine could increase your blood levels of both medications, potentially increasing your risk of side effects. Talk to your healthcare provider about this potential interaction before taking these drugs together.
 
Corticosteroids
Corticosteroids have the potential to cause high blood glucose levels (hyperglycemia), which could make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, if you start or stop taking a corticosteroid. 
 
Digoxin
Taking Janumet XR with digoxin could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to monitor you more closely, especially when you first start or stop taking these drugs together.
 
Diuretics
Because diuretics may increase blood glucose (sugar) levels, taking them with Janumet XR could make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, if you start or stop taking a diuretic medication.
 
Estrogens
Taking Janumet XR with estrogens could make Janumet XR less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, especially when starting or stopping an estrogen.
 
Insulin
Both insulin and Janumet XR can lower blood sugar levels. Thus, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). Although these medicines may be used together to treat diabetes, taking them together may require more careful blood glucose monitoring. Also, your healthcare provider may need to lower your insulin dosage if you take both of these drugs.
 
Insulin Secretogogues
Because insulin secretogogues and Janumet XR can both lower blood sugar levels, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). This doesn't mean these drugs cannot be used together. However, your healthcare provider may need to lower your insulin secretogogue dose if you take it with Janumet XR, or may recommend you monitor your blood glucose levels more closely.
 
Isoniazid
Because isoniazid may cause high blood glucose levels (hyperglycemia), taking it with Janumet XR could make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, if you start or stop taking isoniazid.  
 
Morphine
Taking Janumet XR with morphine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you start or stop taking these drugs together. 
 
Niacin
Taking Janumet XR with niacin can make Janumet XR less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Taking Janumet XR with oral contraceptives (birth control pills) could make Janumet XR less effective, potentially increasing your risk of high blood sugar (hyperglycemia). Talk to your healthcare provider before taking birth control pills during your diabetes treatment, as you may need to be monitored more closely, especially when starting or stopping the oral contraceptive.
 
Phenothiazines
Phenothiazine medications may cause high blood sugar (hyperglycemia), and could therefore make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, especially when you start or stop taking a phenothiazine.  
 
Phenytoin
Phenytoin may cause high blood sugar (hyperglycemia), and could therefore make Janumet XR less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, especially if you start or stop taking phenytoin.  
 
Procainamide
Taking Janumet XR with procainamide could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially when you first start or stop taking these medications together.
 
Quinidine
Taking Janumet XR with quinidine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking these drugs together.
 
Quinine
Taking Janumet XR with quinine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking these medications together.
 
Thyroid Medications
Taking Janumet XR with thyroid medications can make Janumet XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Janumet XR dose, especially when starting or stopping a thyroid medication.
 
Trimethoprim
Taking trimethoprim with Janumet XR could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, especially when first starting or stopping either one.
 
Vancomycin
Taking vancomycin with Janumet XR could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, especially when first starting or stopping either one.
 
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