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Drug Interactions With Irbesartan

More Detail on Interactions With Irbesartan

The following sections explain in detail how various drugs can interact negatively with irbesartan if taken together.
 
Aliskiren
Combining irbesartan with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required. Aliskiren and irbesartan should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate to severe kidney problems.
 
ACE Inhibitors
Combining irbesartan with an ACE inhibitor may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Diuretics
When taking irbesartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when irbesartan is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of irbesartan, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Irbesartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and irbesartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Potassium Supplements
If you are taking a potassium supplement with irbesartan, the levels of potassium in your blood may become too high. This can cause serious problems. Talk to your healthcare provider about using potassium and irbesartan together in your particular situation.
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Irbesartan Information

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