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Invokana and Pregnancy

Is it safe for pregnant women to take Invokana (canagliflozin)? In studies, the drug appeared to affect fetal kidney development and maturation when given to pregnant rats. However, there have not been enough studies to know how this drug may affect humans. Before taking Invokana, talk to your healthcare provider about the benefits and risks in your particular situation.


Can Pregnant Women Take Invokana?

Invokana® (canagliflozin) is a prescription type 2 diabetes medication. Based on the results of animal studies, this medication may not be safe for use during pregnancy.

What Is Pregnancy Category B?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Invokana is classified as a pregnancy Category B medication.
Pregnancy Category B is given to medicines that have not been studied in pregnant humans but do not appear to cause harm to the fetus in animal studies.
Studies in rats suggest that Invokana may affect fetal kidney development and maturation. In particular, problems were seen when the rats were exposed to the drug at times equivalent to the second and third trimesters in humans.
Because Invokana is a relatively new medication, there is little experience with using Invokana in pregnant women. Because animal studies do not always accurately predict what may happen in humans, different information may be available in the future.

Final Thoughts

If you are pregnant or are thinking about becoming pregnant, let your healthcare provider know. He or she will consider the benefits and risks of using Invokana during pregnancy before making a recommendation for your particular situation.
(Click Diabetes and Pregnancy for more information on this topic.)
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