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Precautions and Warnings With Insulin Aspart Protamine/Insulin Aspart

Talk to your healthcare provider about the precautions and warnings with insulin aspart protamine/insulin aspart before starting the drug to help minimize risks. You should also tell him or her if you have liver or kidney disease, as these conditions can affect your dosage. Since low blood sugar can be very dangerous, you must test your blood sugar regularly while taking insulin aspart protamine/insulin aspart.

Insulin Aspart Protamine/Insulin Aspart: What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking insulin aspart protamine/insulin aspart (NovoLog® Mix 70/30, NovoLog® Mix 50/50) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions for Insulin Aspart Protamine/Insulin Aspart

Warnings and precautions to be aware of prior to taking insulin aspart protamine/insulin aspart include the following:
  • Low blood sugar (hypoglycemia) is the most common (and usually most serious) side effect of insulin medications, including insulin aspart protamine/insulin aspart. Make sure you and those around you know how to identify the warning signs for low blood sugar and how to respond. You must test your blood sugar levels regularly while taking insulin aspart protamine/insulin aspart or any other insulin. Low blood sugar levels can be a life-threatening problem.
  • Insulin aspart protamine/insulin aspart starts working quickly. Once you inject a dose of it, you must start eating a meal or snack within 15 minutes, in order to avoid dangerously low blood sugar.
  • Insulin aspart protamine/insulin aspart cannot be used in pumps, injected into a muscle, or used in an IV. Also, do not mix insulin aspart protamine/insulin aspart together with any other type of insulin in the same syringe.
  • Liver and kidney problems may affect your insulin aspart protamine/insulin aspart dosage. Also, changes in diet or exercise, illness, or stress may affect your blood sugar levels in such a way that your dosage needs to be adjusted.
  • Make sure your healthcare provider shows you exactly how to inject the drug, how to store it, and how to dispose of your used needles.
  • This diabetes medication can potentially interact with several other medications (see Drug Interactions With Insulin Aspart Protamine/Insulin Aspart).
  • Insulin aspart protamine/insulin aspart is considered a pregnancy Category C medication. This means it may not be safe for use during pregnancy, although the full risks are not known (see NovoLog Mix 70/30 and Pregnancy).
  • It is not known whether insulin aspart protamine/insulin aspart passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see NovoLog Mix 70/30 and Breastfeeding).
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