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Drug Interactions With Insulin Aspart Protamine/Insulin Aspart

Fibrate cholesterol medications, salicylates, and ACE inhibitors are some of the many medicines that may cause potentially dangerous drug interactions with insulin aspart protamine/insulin aspart. These interactions can result in extremely low blood sugar levels, which can be life-threatening. To minimize your risk of developing insulin aspart protamine/insulin aspart interactions, make sure to tell your healthcare provider any time you start or stop a medication.

Insulin Aspart Protamine/Insulin Aspart Drug Interactions: An Overview

Insulin aspart protamine/insulin aspart (NovoLog® Mix 70/30, NovoLog® Mix 50/50) can potentially interact with several medications, too many to list entirely in this article. Some interactions (which are not discussed in this article) may increase blood sugar levels. While this is not healthy, it is usually not dangerous right away. Other drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). Some of the medicines that may cause dangerously low blood sugar when combined with insulin aspart protamine/insulin aspart include:
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:







  • Monoamine oxidase inhibitors (MAOIs), such as:




    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)


  • Sulfonamide antibiotics ("sulfa drugs"), such as:


    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)


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