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Humulin 50/50 Side Effects

Some of the most common side effects of Humulin 50/50 include a skin reaction, skin thickening, or pitting at the injection site. Although most side effects of this medication are typically minor, some side effects are potentially dangerous. Make sure to notify your healthcare provider if you experience serious side effects while taking Humulin 50/50, such as difficulty breathing, seizures, or blurry vision.

An Introduction to Humulin 50/50 Side Effects

As of July 2009, Eli Lilly and Company decided to stop producing Humulin 50/50 due to low product demand. It was initially estimated that current supplies of the medication may last until April 2010, but the supplies have appeared to have run out earlier than expected (as of December 2009). If you are currently taking Humulin 50/50, your healthcare provider will need to switch you to one of the other types of insulin.


As with any medicine, Humulin® 50/50 (NPH insulin/regular insulin) can cause side effects. While some of the side effects of Humulin 50/50 are relatively minor, some side effects are very dangerous. Learning how to monitor your blood sugar levels and adjust your Humulin 50/50 dosage as necessary can prevent most of the serious side effects.
(This article covers many, but not all, of the possible side effects with Humulin 50/50. Your healthcare provider can discuss a more complete list of Humulin 50/50 side effects with you.)

Possible Side Effects

Possible side effects of all insulins, including Humulin 50/50, include:
  • Skin thickening or pitting at the site of the injection (which may improve with changes in injection technique)
  • A skin reaction at the site of the injection (such as redness, itching, or a temporary lump)
  • Low blood sugar levels (hypoglycemia).
Diabetes Tips for Seniors

Humulin 50/50 Insulin Information

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