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Humalog Warnings and Precautions

Prior to using Humalog, warnings and precautions for the medication should be reviewed with your healthcare provider to help ensure safe treatment. It is also important to know how to use the insulin pump or syringe properly, as well as when and where to inject the medicine. You should also learn to identify the warning signs for low blood sugar and how to respond.

Humalog: What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking Humalog® (insulin lispro) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Humalog

Warnings and precautions to be aware of prior to taking Humalog include the following:
  • Low blood sugar (hypoglycemia) is the most common (and usually most serious) side effect of insulin medications, including Humalog. Make sure you and those around you know how to identify your warning signs for low blood sugar and how to respond. You must test your blood sugar levels regularly while taking Humalog or any other insulin. Low blood sugar levels can be a life-threatening problem.
  • If you use Humalog in an insulin pump, do not dilute it or mix it with other insulins.
  • If you inject Humalog using a syringe (not a pump), you may mix it with certain other insulins. Check with your healthcare provider before mixing insulins. When mixing Humalog with another insulin, you should always draw up Humalog into the syringe first, before the other insulin.
  • Humalog is used to control the spike in blood sugar that occurs after a meal. Once you take a dose of Humalog, you must begin eating the meal within 15 minutes.
  • Liver and kidney problems may affect your Humalog dosage. Also, changes in diet or exercise, illness, or stress may affect your blood sugar levels in such a way that your dosage needs to be adjusted.
  • Make sure your healthcare provider shows you exactly how to inject Humalog, how to store the drug, and how to dispose of your used needles.
  • This diabetes medication can potentially interact with several other medications (see Humalog Drug Interactions).
  • Humalog is considered a pregnancy Category B medication. This means it is most likely safe for use during pregnancy, although the full risks are not known (see Humalog and Pregnancy).
  • It is not known whether Humalog passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Humalog and Breastfeeding).
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