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Humalog Mix50/50 Warnings and Precautions

If you have liver or kidney disease, let your healthcare provider know before using Humalog Mix50/50. Warnings and precautions on how to safely (and accurately) use this form of insulin should also be discussed with your healthcare provider. You should not use Humalog Mix50/50 if you currently have low blood sugar or are allergic to any ingredients used to make the medication.

What Should I Tell My Healthcare Provider Before Taking Humalog Mix50/50?

Talk with your healthcare provider prior to using Humalog® Mix50/50 (insulin lispro protamine/insulin lispro) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
     
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Humalog Mix50/50

Warnings and precautions to be aware of prior to taking Humalog Mix50/50 include the following:
 
  • This medication starts working quickly. Once you inject a dose of Humalog Mix50/50, you must start eating a meal or snack within 15 minutes in order to avoid dangerously low blood sugar.
     
  • Low blood sugar (hypoglycemia) is the most common (and usually most serious) side effect of insulin medications, including Humalog Mix50/50. Make sure you and those around you know how to identify the warning signs for low blood sugar and how to respond. You must test your blood sugar levels regularly while taking Humalog Mix50/50 or any other insulin. Low blood sugar levels can be a life-threatening problem.
     
  • Liver and kidney problems may affect your Humalog Mix50/50 dosage. Also, changes in diet or exercise, illness, or stress may affect your blood sugar levels in such a way that your dose needs to be adjusted.
     
  • Humalog Mix50/50 cannot be used in pumps, injected into a muscle, or used in an IV. Also, do not mix Humalog Mix50/50 with any other type of insulin in the same syringe.
     
  • This diabetes medication can potentially interact with several other medications (see Humalog Mix50/50 Drug Interactions).
     
  • Humalog Mix50/50 is considered a pregnancy Category B medication. This means it is probably safe for use during pregnancy (see Humalog Mix50/50 and Pregnancy).
     
  • It is not known if Humalog Mix50/50 passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Humalog Mix50/50 and Breastfeeding).
     
Diabetes Tips for Seniors

Humalog Mix50/50 Insulin

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