Humalog Mix50/50 Drug Interactions

Fibrate cholesterol medicines, ACE inhibitors, propoxyphene, and many other medications can potentially interact with Humalog Mix50/50. Drug interactions could lead to dangerously low blood sugar, which can be fatal. To help prevent this potentially serious drug interaction, notify your healthcare provider any time you start, stop, or change the dose of any medication while using Humalog Mix50/50.

Drug Interactions With Humalog Mix50/50: An Overview

 Insulin medications, including Humalog® Mix50/50 (insulin lispro protamine/insulin lispro), can potentially interact with numerous different medications -- too many to list here. Essentially, any medication that has the potential to affect blood sugar levels can interact with Humalog Mix50/50.
 
Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy but usually not dangerous right away. Typically, most people will notice higher blood sugar when testing and will adjust their insulin dosage as recommended by their healthcare provider long before these interactions become dangerous.
 
However, other Humalog Mix50/50 drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). These interactions may be dangerous (even fatal), even if you check your blood sugar regularly. Some of the medicines that may cause dangerously low blood sugar when combined with Humalog Mix50/50 include:
 
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
 
 
 
 
 
 
 
 
 
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
 
  • Sulfonamide antibiotics ("sulfa drugs"), such as:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®).
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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