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Glyburide Substitutes

Glyburide (DiaBeta®, Glynase®, Micronase®) is a prescription drug used to treat type 2 diabetes. Most people tolerate the drug well, but it is not the best choice for every situation. Let your healthcare provider know if glyburide does not work for you or if side effects occur so he or she can recommend other options that may be more effective.
If blood sugar levels cannot be controlled with glyburide, substitutes for the medication include lifestyle changes, injectable diabetes medications, and other oral diabetes medicines.
Lifestyle changes include losing weight and making certain dietary changes. Other oral diabetes drugs include:
  • Sulfonylureas
  • Biguanides
  • Meglitinides
  • Thiazolidinediones
  • Alpha glucosidase inhibitors.
Your healthcare provider may also recommend different types of insulin and other injectable medications as a substitute for glyburide. Besides insulin, these options include:
  • Incretin mimetics
  • Amylin analogues.
(To learn about other substitutes for this medication, click Glyburide Alternatives. This article offers a more detailed list of the various medications and lifestyle changes that can be used to treat type 2 diabetes.)
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