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Drug Interactions

Glyburide can potentially interact with a number of medicines (see Glyburide Drug Interactions).

What Should I Tell My Healthcare Provider Before Taking Glyburide?

You should talk with your healthcare provider prior to taking this drug if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Glucose 6-phosphate dehydrogenase (G6PD) deficiency 
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant (see Glyburide and Pregnancy)
  • Are breastfeeding
  • Will be having surgery.
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Glyburide Warnings and Precautions to learn more, including information on who should not take the drug.)

Are There Alternatives?

In general, treatment for type 2 diabetes begins with lifestyle changes (for example, weight loss, exercise, and diet). If lifestyle changes alone are not effective in managing diabetes, medication may be necessary.
The main goal of diabetes medicine is to lower blood sugar levels enough to reduce your risk of developing problems related to diabetes, such as heart, nerve, eye, or kidney problems. Because glyburide can lower blood sugar levels, people may be able to lower their risk of developing problems related to high blood sugar by taking it.
Glyburide is quite effective at controlling blood sugar. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, you may need to combine glyburide with another diabetes medicine, such as metformin (Glucophage®) or insulin. You may also wish to consider a substitute. These substitutes could include other sulfonylureas or other diabetes drugs, either by themselves or in combination.
(Click Glyburide Alternatives to learn more.)
To learn about controlling diabetes through lifestyle choices, click the following eMedTV links:
7 Signs of High Blood Sugar

Glyburide Medication Information

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