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Glyburide Drug Interactions

If other medications are taken with glyburide, drug interactions are possible. For example, a combination of glyburide with beta blockers, certain decongestants, and oral contraceptives can cause the body to metabolize the medications differently than intended and increase the risk of low blood sugar or make glyburide less effective. If glyburide drug interactions are a concern, your healthcare provider may adjust your dosages.

An Overview of Glyburide Drug Interactions

Glyburide (DiaBeta®, Glynase®, or Micronase®) can potentially interact with other medications. Some of the drugs that may lead to glyburide drug interactions include:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)


  • Estrogens 
  • Fluoroquinolone antibiotics, including:


  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
  • Sulfonamides ("sulfa drugs"), including:
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
  • Thyroid medications, such as:
Common Symptoms of Diabetic Neuropathy

Glyburide Medication Information

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