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Glyburide Drug Interactions

Nonsteroidal Anti-Inflammatory Drugs
Taking glyburide and NSAIDs together can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when stopping or starting an NSAID, depending on your particular situation.
 
Oral Contraceptives
Combining glyburide with oral contraceptives (birth control pills) can make glyburide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
If glyburide is combined with phenothiazines, this can make glyburide less effective, which may increase your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a phenothiazine, to prevent this interaction from occurring.
 
Phenytoin
Taking glyburide and phenytoin together can make glyburide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping phenytoin.
 
Probenecid
Taking glyburide with probenecid can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping probenecid.
 
Rifampin
Rifampin may cause the body to metabolize glyburide more quickly than normal, making glyburide less effective. Check with your healthcare provider before taking rifampin with glyburide.
  
Salicylates
If glyburide and salicylates are combined, this can increase your risk of low blood sugar (hypoglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a salicylate.
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Glyburide Medication Information

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