Glyburide and Pregnancy: An Overview
, or Micronase®
) may not be safe for women to take during pregnancy. This is based on animal studies that looked at the effects of the drug on pregnancy. However, the safety of glyburide use
during pregnancy is a complex issue.
Glyburide and Pregnancy Categories B and C
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. DiaBeta has been classified as a pregnancy Category C medication. Glynase, Micronase, and generic glyburide
have been rated as pregnancy Category B medications. At first thought, this seems impossible, since all three products contain the same active ingredient in similar amounts.
Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that appear to cause harm to the fetus based on animal studies. Pregnancy Category B medications have not been studied in pregnant women either, but they do not appear to cause harm to the fetus based on animal studies. It is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category B or Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the mother outweigh any possible risks to the unborn child.