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Glyburide and Pregnancy

Glyburide and Pregnancy: Why the Different Ratings?

Medications are classified as pregnancy category medications based on studies. Even studies with the same medication can show different results, depending on several factors. In the studies done by the maker of DiaBeta, giving glyburide to pregnant rats caused problems in the bones of baby rats. When the makers of Glynase and Micronase did similar animal studies, glyburide did not cause any problems. It does not really make sense that these medications have different pregnancy categories, but the FDA has never remedied this discrepancy.
At this point, insulin is still the recommended treatment of choice in pregnant women with diabetes. However, more and more healthcare providers are using glyburide for diabetes during pregnancy, as it is much easier to use than insulin injections. Slowly, a few of the guidelines are starting to mention glyburide as an option for use in pregnant women.

Glyburide and Pregnancy: Suggestions

If you are taking glyburide and become pregnant, or are thinking about becoming pregnant, let your healthcare provider know. He or she will consider the benefits and the risks of taking glyburide during pregnancy before making a recommendation for your particular situation.
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