Glucovance

What Is Glucovance?

Glucovance^® (glyburide and metformin) is a prescription medication that is used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes). Glucovance is a combination of two different diabetes medications: glyburide (DiaBeta^®, Glynase^®, or Micronase^®) and metformin hydrochloride (Fortamet^®, Glucophage^®, Glucophage XR^®, Glumetza^®, or Riomet^®).

(Click Glucovance Uses for more information on what the drug is used for, including possible off-label uses.)

Glucovance is manufactured by Bristol-Myers Squibb Company.

Glucovance is a combination of two diabetes medicines (glyburide and metformin).

These two medications work differently and have different effects in the body:

Glyburide is part of a class of diabetes drugs called sulfonylureas. A sulfonylurea, such as glyburide, helps the pancreas make more insulin. It also helps the cells of the body respond better to insulin. This helps to lower blood sugar and keep it under better control.
Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. It can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, helping the body respond better to its own insulin. All of these effects cause a decrease in blood sugar levels.

Glucovance is not used for type 1 diabetes treatment.