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Glucovance Drug Interactions

Glucovance drug interactions can increase your risk of low blood sugar, make Glucovance less effective, and raise your risk of side effects, among other things. A few of the drugs that can potentially interact with Glucovance include beta blockers, calcium channel blockers, and certain decongestants. You should be sure to talk with your pharmacist or healthcare provider about any drug interactions with Glucovance that may apply to you.

An Overview of Glucovance Drug Interactions

Glucovance® (glyburide and metformin) can potentially interact with a number of other medicines. Some of the medicines that can lead to Glucovance interactions include:






    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)


  • Diuretics, such as:



  • Estrogens
  • Fluoroquinolone antibiotics, including:



  • Isoniazid
  • Monoamine oxidase inhibitors (MAOIs), including:



  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:





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Glucovance Drug Info

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