Glucovance Drug Interactions

Glucovance drug interactions can increase your risk of low blood sugar, make Glucovance less effective, and raise your risk of side effects, among other things. A few of the drugs that can potentially interact with Glucovance include beta blockers, calcium channel blockers, and certain decongestants. You should be sure to talk with your pharmacist or healthcare provider about any drug interactions with Glucovance that may apply to you.

 

An Overview of Glucovance Drug Interactions

 Glucovance® (glyburide and metformin) can potentially interact with a number of other medicines. Some of the medicines that can lead to Glucovance interactions include:
 
  • Beta blockers, such as:

 

 

 

 

  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Cimetidine (Tagamet®)
     
  • Corticosteroids, such as:

 

    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

 

  • Diuretics, such as:

 

 

  • Estrogens
     
  • Fluoroquinolone antiobiotics, including ciprofloxacin (Cipro®), gatifloxacin (Tequin®), levofloxacin (Levaquin®), moxifloxacin (Avelox®), norfloxacin (Noroxin®), and ofloxacin (Floxin®)
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

 

 

  • Phenytoin (Dilantin®)
     
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Salicylates, such as aspirin, choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
     
  • Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar®), sulfamethoxazole (Bactrim®, Septra®), and sulfisoxazole (Gantrisin®)
     
  • Thyroid medications, such as levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®), liothryonine (Cytomel®), thyroid (Armour® Thyroid), and liotrix (Thyrolar®)
     
  • Warfarin (Coumadin®, Jantoven®).
     
(Glucovance Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;