Low blood sugar is a known problem in some people taking Glucovance -- and it can cause serious or even life-threatening complications. Prevention is the best treatment. Therefore, if you are taking Glucovance, you should be aware that low blood sugar is a possible side effect of the drug. You should also know the possible signs and symptoms of low blood sugar and know what to do if these symptoms occur. Finally, it is important that you know how to check your blood sugar levels.