Side Effects of Glipizide

Although most people tolerate the drug without problems, side effects of glipizide are possible, such as dizziness, diarrhea, and nervousness. In many cases, these side effects are minor and easily treated by you or your healthcare provider. However, some glipizide side effects should be reported to your doctor, including chest pain, shortness of breath, or signs of an allergic reaction.

Glipizide Side Effects: An Introduction

As with any medicine, side effects are possible with glipizide (Glucotrol®) or glipizide extended-release (Glucotrol XL®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with glipizide. Your healthcare provider can discuss a more complete list of glipizide side effects with you.)
 

Serious Side Effects of Glipizide

Serious side effects of glipizide, while occurring infrequently, are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
 
  • Symptoms of high blood sugar, such as:
 
    • Increased hunger
    • Increased thirst
    • Increased urination
    • Blurred vision
    • Fatigue
    • Shortness of breath
    • Nausea or vomiting
 
  • Symptoms of low blood sugar, such as:
 
    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures

 

  • Signs of liver damage, such as:
     
    • Yellow skin or eyes (jaundice)
    • Unusually dark urine
    • Upper-right abdominal pain (stomach pain)
    • Easy bruising or bleeding 
 
  • Signs of an allergic reaction, such as:
 
    • An unexplained skin rash
    • Itching
    • Hives
    • Wheezing or difficulty breathing
    • Unexplained swelling
 
  • Fever, chills, or sore throat
  • Chest pain
  • Shortness of breath
  • Fast heartbeat or heart palpitations.
 
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