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Side Effects of Glipizide

Common Side Effects of Glipizide

Glipizide has been studied thoroughly in clinical trials in which the side effects reported by a group of people taking the drug are documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Based on the studies of extended-release glipizide, the most common side effects include:
  • Dizziness -- occurring in up to 6.8 percent of people
  • Diarrhea -- in up to 5.4 percent
  • Nervousness -- in up to 3.6 percent
  • Tremor or shakiness -- in up to 3.6 percent
  • Gas -- in up to 3.2 percent.
Other common side effects of glipizide (occurring in 1 to 3 percent of people) include:

Rare Side Effects of Glipizide

Rare glipizide side effects have happened in only a few people taking the drug. Because these side effects are so uncommon, it is difficult to tell whether they are caused by glipizide or something else.
Based on the studies of extended-release glipizide, some of these rare side effects include but are not limited to:
    • Stomach upset
    • Vomiting
    • Shakiness
    • Sweating
    • Stomach cramps.
Oral diabetes medications, including glipizide, may increase the risk of death due to heart or blood vessel problems, compared to diabetes treatment with diet or insulin. This warning is based on one research study that looked at a medication similar to glipizide. However, it is unclear at this time how important this risk may be in people taking glipizide.
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