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How Does Glipizide Work?

Glipizide (Glucotrol®) is often used for people with type 2 diabetes when blood sugar cannot be controlled by diet and exercise alone. The medicine can be used alone or in combination with other diabetes medications.
To understand how glipizide works, it helps to start with some background on type 2 diabetes, a condition involving insulin resistance. With insulin resistance, the cells of the body do not respond to insulin as well as they normally should. As a result, the cells do not take sugar out of the blood very well. This is why people with the condition have high blood sugar.
Glipizide works by increasing the production of insulin in the pancreas. It may also help to lower blood sugar by improving insulin resistance. This means that this medicine can help the cells take more sugar from the blood.
(To learn more about how this medication works, click Glipizide. Other topics discussed in this article include dosing guidelines, what to expect in cases of overdose, available forms of glipizide, and more.)
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