Glipizide Sexual Side Effects

During extensive clinical studies of glipizide, sexual side effects were reported in less than 1 percent of people taking the extended release form of the drug. However, sexual side effects were not reported by people taking short-acting glipizide. Because these glipizide sexual side effects occur so infrequently, it is difficult to know whether these problems are caused by another condition, glipizide itself, or a combination of both.

An Overview of Glipizide Sexual Side Effects

Glipizide (Glucotrol®) and glipizide extended release (Glucotrol XL®) are prescription medications used to treat type 2 diabetes. As with all medicines, side effects of glipizide are possible. Some of these side effects can affect a person's sexual well-being. In the case of glipizide, a decreased libido (sex drive) has been reported as a rare side effect.
 

How Common Are Glipizide Sexual Side Effects?

Before medicines are approved, they must go through several clinical studies, where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, the side effects are always documented. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In clinical studies, a decreased libido (sex drive) was reported in less than 1 percent of people taking glipizide extended release. In studies of the short-acting form of glipizide, no sexual side effects were reported.
 

Glipizide, Sexual Side Effects, and Suggestions

It is impossible for your healthcare provider to know whether you will develop any sexual side effects while taking glipizide. Because sexual side effects of the medication occur so infrequently, it is difficult to know whether these problems are caused by another condition, glipizide itself, or a combination of both.
 
However, if you are taking glipizide and sexual side effects occur, talk with your healthcare provider. He or she may be able to recommend certain treatments. Depending on the severity of your sexual side effects, your healthcare provider may also recommend that you adjust your glipizide dosing or try one of the glipizide alternatives.
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