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Drug Interactions

Glipizide can potentially interact with a number of medicines (see Glipizide Drug Interactions).

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking glipizide if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Narrowing or strictures in the digestive tract
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Glipizide Warnings and Precautions to learn more, including information on who should not take the drug.)

Alternatives to Glipizide

In general, treatment for type 2 diabetes begins with lifestyle changes (for example, weight loss, exercise, and diet). If lifestyle changes alone are not effective in managing diabetes, medication such as glipizide may be necessary.
The main goal of diabetes medicine is to lower blood sugar levels enough to reduce your risk of developing problems related to diabetes, such as heart, nerve, eye, or kidney problems. Because glipizide can lower blood sugar levels, people may be able to lower their risk for developing problems related to high blood sugar by taking it.
The medication is usually quite effective at controlling blood sugar. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, you may need to combine glipizide with another diabetes medicine, such as metformin (Glucophage®) or insulin. You may also wish to consider a substitute. These could include other sulfonylureas or other diabetes drugs, either by themselves or in combination.
(Click Glipizide Alternatives to learn more.)
To learn about controlling diabetes through lifestyle choices, click any of the following links:
Healthy Eating for People With Diabetes

Glipizide Diabetic Medication

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