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Glipizide Drug Interactions

Glipizide Interactions Explained

The following sections explain in detail the following interactions that can occur when glipizide is combined with any of the drugs listed above.
 
Beta Blockers
Taking glipizide with beta blockers can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide dose, especially when starting or stopping a beta blocker.
 
Calcium Channel Blockers
Combining glipizide with calcium channel blockers can make glipizide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide dose, especially when starting or stopping a calcium channel blocker, to prevent this interaction from occurring.
 
Certain Decongestants
If glipizide is taken with certain decongestants, this can make glipizide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide dose, especially when starting or stopping decongestants. To prevent this interaction, check with your healthcare provider before using an over-the-counter cough or cold product, as many of these medications contain decongestants.
 
Colesevelam
Colesevelam interferes with the absorption of glipizide into the body, perhaps making it less effective. To avoid this interaction, be sure to take glipizide at least four hours before colesevelam.
 
Corticosteroids
Taking glipizide and corticosteroids together can make glipizide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide dose, especially when starting or stopping a corticosteroid.
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