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Glipizide and Depression

In clinical studies on glipizide, depression was reported in up to 3 percent of people taking the long-acting form of the drug. However, depression was not reported in people taking the short-acting form. Because depression is so common in the general population, if you are taking glipizide and depression symptoms (such as a persistent sad mood or feelings of helplessness) occur, talk to your healthcare provider.

Glipizide and Depression: An Overview

Several side effects are possible for people taking glipizide (Glucotrol®) or glipizide extended release (Glucotrol XL®). Depression appears to be one of the more common side effects reported in clinical studies of glipizide extended release.
 

Glipizide and Depression: Understanding Clinical Studies

Before medicines are approved, they must go through several clinical studies in which thousands of people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, side effects are always documented. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. Side effects are then usually separated into those that occurred in more than 1 percent of people (common side effects) and those that occurred in less than 1 percent of people (rare side effects).
 
For people taking glipizide extended release, depression was a reported side effect, occurring in up to 1 to 3 percent of people taking the drug (the exact percent was not reported). Depression was not reported as a side effect in people taking the short-acting form of glipizide, however.
 
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