Exubera Drug Interactions

Exubera drug interactions with other medications, such as ACE inhibitors, thyroid medications, and oral contraceptives, can cause the body to metabolize the drugs differently than intended. These interactions can either raise or lower your blood sugar levels or make Exubera less effective. If Exubera drug interactions are a concern, your healthcare provider may adjust your dose, especially when starting or stopping another medication.

In October 2007, Pfizer announced it will stop making Exubera. This decision was voluntary and was not based on any safety concern; Pfizer states that Exubera has not met its expectations in terms of sales. Starting in October 2007, Exubera will be available for an additional three months, which will give people enough time to change from Exubera to another type of insulin or other diabetes medication.
 

An Overview of Exubera Drug Interactions

Exubera® (
 inhaled insulin) can potentially interact with several medications. Some of the drugs that can lead to Exubera interactions include:
 
  • ACE inhibitors, including:
 
 
 
 
 
 
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®) 
 
  • Danazol (Danocrine®)
     
  • Diuretics, such as:
 
 
 
 
 
 
  • Propoxyphene (Darvon®, Darvocet®)
     
  • Protease inhibitors, such as:
 
 
  • Salicylates, such as:
 
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
 
  • Sulfonamides ("sulfa drugs"), including:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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