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Exubera Dosing

When starting the drug, Exubera dosing guidelines call for a dose that is based on a person's body weight. However, other factors can affect dosing as well, such as whether you have type 1 or type 2 diabetes, have other medical conditions, or are taking other medications. Because the drug works quickly, you should inhale your Exubera dose within 10 minutes before a meal.

In October 2007, Pfizer announced it will stop making Exubera. This decision was voluntary and was not based on any safety concern; Pfizer states that Exubera has not met its expectations in terms of sales. Starting in October 2007, Exubera will be available for an additional three months, which will give people enough time to change from Exubera to another type of insulin or other diabetes medication.
 

An Overview of Exubera Dosing

The dosage of Exubera® (inhaled insulin) that your healthcare provider prescribes will vary, depending on a number of factors, including:
 
  • Whether you have type 1 or type 2 diabetes
  • Other medical conditions you may have
  • Other medications you are currently taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you do to so.
 

Exubera Dosing for Diabetes

As with all insulins, your dose will need to be adjusted for your particular situation. The dose of short-acting (or rapid-acting) insulins are figured in many different ways. For example, some people count carbohydrates to adjust their insulin dose. You and your healthcare provider will decide the best way for you. The following table outlines estimates of the recommended starting Exubera doses (based on body weight):
 
Weight
Starting Exubera Dose
Blisters
66 to 87 pounds
1 mg per meal
One 1-mg blister
88 to 132 pounds
2 mg per meal
Two 1-mg blisters
133 to 176 pounds
3 mg per meal
One 3-mg blister
177 to 220 pounds
4 mg per meal
One 1-mg blister plus one 3-mg blister
221 to 264 pounds
5 mg per meal
Two 1 mg-blisters plus one 3-mg blister
265 to 308 pounds
6 mg per meal
Two 3-mg blisters
 
For people who are switching from short-acting injectable insulin, the starting Exubera dose can be calculated based on the previous insulin dose. The 3-mg blister is approximately equal to 8 units of regular insulin, and the 1-mg blister is approximately equal to 3 units of regular insulin. It is important to note that three of the 1-mg blisters do not equal one of the 3-mg blisters.
 
At this time, the 1-mg and 3-mg blisters cannot be purchased separately (they will come in a pack together). You need to use them in such a way that you use the minimum number of blisters as possible per dose. Remember: three 1-mg blisters are not equal to one 3-mg blister. In studies, people absorbed more insulin when using three 1-mg blisters, rather than one 3-mg blister. If you run out of 3-mg blisters (or if they become temporarily unavailable), use two 1-mg blisters in place of one 3-mg blister until more 3-mg blisters can be obtained. Unfortunately, many people will end up with blisters that they cannot use because the two strengths cannot be purchased separately.
 
Type 2 Diabetes: Fact or Fiction

Exubera Drug Information

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