Duetact Drug Interactions

When certain medications are taken with Duetact, drug interactions may develop that can lead to serious side effects. Medicines that may potentially cause negative interactions include corticosteroids, beta blockers, diuretics, and nonsteroidal anti-inflammatory drugs. These Duetact drug interactions can increase or decrease the level of Duetact in your system, make the medicines less effective, or cause extremely high or low blood sugar.

 

Duetact Drug Interactions: An Overview

 Duetact® (pioglitazone and glimepiride) can potentially interact with several medicines. Some of the medicines that may lead to Duetact drug interactions include:
 
 
 
  • Certain antifungals, including fluconazole (Diflucan®), ketoconazole (Nizoral®), and miconazole
     
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Certain seizure medications, including:
 
 
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®).
 
  • Diuretics, such as:
 
 
  • Estrogens
     
  • Gemfibrozil (Lopid®)
     
  • Isoniazid
     
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Rifampin (Rifadin®) or rifapentine (Priftin®)
     
  • Ritonavir (Norvir®)
     
  • Thyroid medications, such as:
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Duetact Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;