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Diabetes Insipidus

Treatment for Nephrogenic Diabetes Insipidus
Desmopressin will not work for this type of diabetes insipidus. Instead, you may be given a drug called hydrochlorothiazide (also called HCTZ) or indomethacin. HCTZ is sometimes combined with another drug called amiloride. This combination is sold under the brand name Moduretic®. Again, with this combination of drugs, you should drink fluids only when you are thirsty and not at other times.
 
Treatment for Dipsogenic Diabetes Insipidus
Desmopressin or other drugs should not be used to treat dipsogenic diabetes insipidus because it may decrease urine output but not thirst and fluid intake. This fluid "overload" can lead to water intoxication, a condition that lowers the concentration of sodium in the blood and can seriously damage the brain.
 
Treatment for Gestational Diabetes Insipidus
Most cases of gestational diabetes insipidus can be treated with desmopressin. In rare cases, however, an abnormality in the thirst mechanism causes this type, and desmopressin should not be used.
 

Final Thoughts

The following points are important to keep in mind regarding diabetes insipidus:
 
  • This is a rare condition caused by the kidneys' inability to filter urine.
  • Common symptoms include excessive urination and increased thirst.
  • Types of diabetes insipidus include central, nephrogenic, dipsogenic, and gestational.
  • A diagnosis is based on a series of tests, including urinalysis and a fluid deprivation test.
  • Treatment options depend on the type of diabetes insipidus with which a person is diagnosed.
     
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Information about Diabetes Insipidus

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