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Diabetes Insipidus

Nephrogenic Diabetes Insipidus
This form results when the kidneys are unable to respond to ADH. The kidneys' ability to respond can be impaired by drugs (like lithium, for example) and by chronic disorders, including:
 
  • Polycystic kidney disease
  • Sickle cell disease
  • Kidney failure
  • Partial blockage of the ureters
  • Inherited genetic disorders.
     
Sometimes, however, the cause of nephrogenic diabetes insipidus is never discovered.
 
Dipsogenic Diabetes Insipidus
A third type of diabetes insipidus is caused by a defect in or damage to the thirst mechanism, which is located in the hypothalamus. This defect results in an abnormal increase in thirst and fluid intake that suppresses ADH secretion and increases urine output. This is a more rare form of diabetes insipidus.
 
Gestational Diabetes Insipidus
A fourth type occurs only during pregnancy. Gestational diabetes insipidus, which is also rare, occurs when an enzyme made by the placenta destroys ADH in the mother. The placenta is the system of blood vessels and other tissue that develops with the fetus. The placenta allows the exchange of nutrients and waste products between the mother and the fetus.
 

Symptoms of Diabetes Insipidus

Diabetes insipidus causes frequent urination. The large volume of urine is diluted and mostly water. To make up for lost water, you may feel the need to drink large amounts. You are likely to urinate frequently, even at night, which can disrupt sleep or, on occasion, cause bedwetting. Because of the excretion of abnormally large volumes of dilute urine, you may quickly become dehydrated if you do not drink enough water.
 
Children with diabetes insipidus may be irritable or listless and may experience fever, vomiting, or diarrhea.
 
Type 2 Diabetes: Fact or Fiction

Information about Diabetes Insipidus

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