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Diabetes Insipidus

Understanding Fluid Regulation in the Body

Your body has a complex system for balancing the volume and composition of body fluids. Your kidneys remove extra body fluids from your bloodstream. This fluid waste is stored in the bladder as urine. If your fluid regulation system is working properly, your kidneys make less urine to conserve fluid when the body is losing water. Your kidneys also make less urine at night when the body's metabolic processes are slower.
In order to keep the volume and composition of body fluids balanced, the rate of fluid intake is governed by thirst, and the rate of excretion is governed by the production of antidiuretic hormone (ADH), also called vasopressin. This hormone is made in the hypothalamus, a small gland located in the base of the brain. ADH is stored in the nearby pituitary gland and released from it into the bloodstream when necessary. When ADH reaches the kidneys, it directs the kidneys to concentrate the urine by returning excess water to the bloodstream and, therefore, make less urine.

Types of Diabetes Insipidus

Diabetes insipidus occurs when the precise system for regulating the kidneys' handling of fluids is disrupted (see Causes of Diabetes Insipidus).
The different types include:
  • Central
  • Nephrogenic
  • Dipsogenic
  • Gestational.
Central Diabetes Insipidus
The most common form of clinically serious diabetes insipidus, central diabetes insipidus, results from damage to the pituitary gland, which disrupts the normal storage and release of ADH. Damage to the pituitary gland can be caused by different diseases as well as by head injuries, neurosurgery, or genetic disorders.
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Information about Diabetes Insipidus

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